Altitude sickness

The International Society for Mountain Medicine is a group looking into these questions scientifically. Their working definitions are:

High altitude: 1500–3500 m (5000–11,500 ft)

Very high altitude: 3500–5500 m (11,500–18,000 ft)

Extreme altitude: above 5500 m (above 18,000 ft)

Altitude sickness rarely occurs below 2500 m (8000 ft).

A minority of people, about 20%, have some symptoms of altitude sickness if they ascend to about 2500 m (8000 feet) above sea level and sleep there. (This is the level of cabin pressurisation of most commercial aircraft apart from the Airbus A380 and Boeing 787). However, most people will acclimatize to 3000 m (10,000 feet) with relative ease, perhaps having symptoms after the first night.

Acclimatizing to heights of 3000–5000 m (10,000–16,000 feet) is much more difficult, and it is here that it is absolutely necessary to ascend slowly and return to a lower altitude to sleep if you have been travelling around at a higher altitude during the day. Over 50% of people will become ill if they ascend rapidly from sea level to 3500 m (11,000 feet) without acclimatization, and everyone will if they ascend rapidly to 5000 m (16,000 feet).

It is thought to be impossible to permanently acclimatize to heights above 5500 m (18,000 feet). It is possible to spend several weeks sleeping as high as 6000 m (20,000 feet) once acclimatized, but gradual deterioration of physical well-being will still occur. Only serious mountain climbers will go that high, though. Almost no-one lives above 5000 m, though some nomadic Tibetan herders spend summers that high.

Death rates from altitude sickness above 7000 m (23,000 feet) are estimated at 4% of all people who venture that high. Regions above 8000 m (26,000 feet) are referred to as the death zone: you will deteriorate noticeably while you remain at such high altitudes, some of your body's major systems will shut down and climbers will only remain there for two or three days. However, the world has only 14 mountains over 8000 m.

If your home is significantly above sea level, you gain a definite leg up on ascending to higher elevations, but that doesn't make you immune to altitude problems; it just pushes the threshold for their onset higher. Most otherwise healthy people who live at elevations of 1500 m (5000 feet) to 2500 m (8000 feet), an elevation range containing quite a few major cities, experience little trouble going to 3000 m (10,000 feet) or a bit higher, but even they will be at risk of altitude problems at 5000 m (16,000 feet).

Past performance at altitude is the main predictor of future performance, but is a guide, not a guarantee. Beware that even if you have not suffered acute mountain sickness (AMS) in the past at altitude, you may still suffer it in future, even at lower altitudes.

Altitude sickness tends to affect men more than women, especially men between the ages of 16 and 25. It’s not clear if there’s some unknown biological reason for this, or if it’s just the demographic most likely to attempt too much, too soon. It is important to remember that just because you are young and healthy, and haven’t experienced altitude sickness in the past doesn’t mean you are immune to it on future climbs. Physical fitness is not necessarily a good indicator, and neither are strength or good health. You may react badly to altitude despite being fit, young and healthy. In fact, the fit, young and healthy have a hidden risk: their general physical capacity leads them to believe that they should handle altitude just fine, which is not always true.

Bad health, on the other hand, is a risk factor: particularly cardiac or respiratory problems. Healthy hearts and lungs have a hard enough time getting oxygen to your tissues at high altitudes. Naturally, if you have physical problems that make exertion difficult for you, you have reason to think carefully about exertion at high altitude, where it is much harder!

Scuba diving increases risk of decompression sickness. If you have recently been diving and have not fully gotten rid of the nitrogen in your blood, you should not ascend to a higher altitude (or travel in a plane). See scuba diving for recommendations on how long to wait.

Genetics play a role: ethnic groups native to higher elevations, notably Sherpas and Tibetans have significant genetic adaptations to altitude, and at least eight genetic polymorphisms have been identified as contributing to individual variation: AMS is an environmentally mediated polygenetic disorder. However, for most people there is no screening, genetic or otherwise, available to assess risk for altitude sickness. Thus prior history is used instead.

Other than mountain climbing and other mountain sports, such as skiing, the main travel destinations at high altitudes are Bolivia, Peru (in the Bolivian Plateau), and the Tibetan Plateau (Qinghai and Tibet in China), all of which have significant destinations around 3500 m, high enough to pose significant risk of altitude sickness. By contrast, other mountainous destinations such as Mongolia, Nepal, Switzerland (mostly below 2000 m), and even Bhutan (around 2500 m), are mostly settled at lower elevation, especially in valleys, and pose at most mild risk of altitude sickness.

For flying into Peru for the Inca Trail, Cusco (3400 m) is quite high (over 50% risk of AMS), and immediately hitting the Inca Trail is dangerous, occasionally resulting in death. Safer is to leave Cusco and acclimate for a night or two in the Sacred Valley, before returning to Cusco, and thence the Inca Trail. Machu Picchu (2400 m) is not very high, however.

For flying into Tibet, notably Lhasa (3650 m), directly flying from sea level poses a greater than 80% risk of AMS. Acclimating for a few days in the major cities of Kunming (2000 m) or Xining (2300 m) helps, but safest and most enjoyable is to follow the Yunnan tourist trail to Zhongdian (3200 m) and fly from there to Lhasa. If you spend a night or two each in Kunming (2000 m), Dali (2400 m) or Lijiang (2400 m), and Zhongdian (3200 m) to acclimatise (particularly in Zhongdian), you should be able to fly to Lhasa with little risk. Taking the train into Tibet does not help: it is first too low, then too high to help acclimation.

For flying into La Paz, Bolivia, acclimate in the low, southern part of town (such as Calacoto or Obrajes) for a few nights.

In terms of large cities, there are under a dozen large cities (at least 100,000 population) above 3000 m, of which the most significant are La Paz (Bolivia, 3650 m), Lhasa (Tibet, 3650 m), and Cusco (Peru, 3400 m). The countries with many major cities above 2000 m are Bolivia, Peru, China (Tibetan Plateau), Ecuador, Colombia, and Mexico, while Eritrea, Ethiopia, Guatemala, and Yemen all have 1–3 major cities (capital or second city) at 2000–3000 m, and Afghanistan and India have a few minor cities at altitude.

In the US, Denver, Colorado is nicknamed the "mile-high city", but a mile is only slightly above 1600 m. The country's only higher city of 100,000 or more is also in Colorado, namely Colorado Springs. While downtown is at about 1840 m, some non-mountainous area destinations are noticeably higher, notably the nearby U.S. Air Force Academy, whose football stadium is at slightly over 2000 m and its main cadet area at nearly 2200 m.

Comparative elevations of significant travel destinations.

Morocco

Jebel Toubkal (4167 m) — Africa's highest mountain not located in the East Central part of the continent, accessible by hiking in the summer.

Tanzania

Mount Kilimanjaro (5895 m) — the summit of Africa's highest mountain can be reached by just hiking; in fact the record for an ascent and descent is less than seven hours! Hence, it’s easy to get dangerously high in a short time.

Afghanistan

Wakhan Corridor (around 4000 m)

The Hindu Kush (mostly in Afghanistan, partly Pakistan and Tajikistan) includes 11 peaks over 6000m

The Salang Pass has been the main route through the Hindu Kush, connecting Central Asia (specifically Bactria) and Afghanistan, for thousands of years. The pass itself is at almost 3900m but today you can avoid going that high by taking the Salang Tunnel which is at about 3400m.

Bhutan

Thimphu (2250–2650 m)

China

Yunnan tourist trail: Kunming (2000 m), Dali (2400 m), Lijiang (2400 m), Zhongdian (3200 m), Deqin (3550 m)

Three parallel rivers, also in Yunnan, off the main tourist trail but popular for hikers (several peaks over 6000 m)

Tibet: The entire Tibetan plateau averages 4500 m, with capital Lhasa at around 3650 m. All rail and road routes to the plateau require crossing passes over 5000 m.

Japan

Mount Fuji (3776 m) – Japan’s highest mountain, generally climbed in a single overnight hike, high enough to cause sickness.

Kyrgyzstan

Song Kol Lake (3016 m)

Nepal

The country has eight of the world's ten tallest mountains including the highest of all, Mount Everest at 8849 m.

The main cities, Kathmandu and Pokhara, are both under 1500 m.

Some popular treks involve quite high altitudes; for example the Everest base camp is over 5000 m.

See Trekking in Nepal for more detail.

Pakistan

Gilgit-Baltistan, a popular region for trekking with several peaks over 8000 m. The K2 base camp trek is in this region.

Tajikistan

Gorno-Badakhshan (Pamirs) - Several peaks within this region are above 7000 m, and while the Pamir Highway snakes through the valleys the whole plateau is quite high above sea level

The Swiss and French Alps do have some ski resorts and viewpoints at risky altitudes with fast cable car or train access from the valley (usually around 1000 m), resulting in extremely rapid ascent to significant altitudes, for instance Aiguille du Midi (3842 m) or Jungfraujoch (3454 m).

Mexico

Mexico City (2233 m)

Pachuca (2400 m)

Puebla (2135 m)

Tlaxcala (2239 m)

United States

Arizona

South Rim of the Grand Canyon: Averages about 7,000 ft/2,100 m; visitor center at 7,106 ft/2,166 m. Open year-round.

North Rim of the Grand Canyon: Averages over 8,000 ft/2,440 m; visitor center at 8,238 ft/2,511 m. Open only from May–October due to extreme snowfall.

California

Mount Whitney (14,505 feet/4,421 m), the highest point in the Lower 48 is accessible by just hiking.

Colorado

Many high ski resorts, e.g., Breckenridge (~3000–4000 m)

Aspen (2400 m)

Argentina

Aconcagua (6961 m) – highest mountain outside of Asia. Technically easy to climb, so can get dangerously high in a short time.

Bolivia

La Paz (3650 m) – highest capital city

El Alto (4150 m) – highest major metropolis, satellite city of La Paz

Potosí (4000 m)

Oruro (3735 m)

Sucre (2790 m)

Cochabamba (2558 m)

Chile

Ojos del Salado (6893 m) - South America's second highest peak is possibly the highest place in the world you can reach without climbing.

Colombia

Bogotá (2565 m)

Tunja (2810 m)

Duitama (2535 m)

Sogamoso (2569 m)

Pasto (2540 m)

Ipiales (2903 m)

Manizales (2124 m)

Ecuador

Quito (2850 m)

Papallacta (3200 m)

Ibarra (2200 m)

Otavalo (2400 m)

Cuenca (2500 m)

Loja (2073 m)

Riobamba (2760 m)

Ambato (2600 m)

Latacunga (2773 m)

Quilotoa Lagoon (3870 m)

Peru

Cajamarca (2725 m)

Ayacucho (2300 m)

Huancayo (3200 m)

Cerro de Pasco (4300 m)

Puno (3800 m)

Juliaca (3800 m)

Abancay (2100 m)

Huaraz (3100 m)

Arequipa (2328 m)

Cusco (3350 m)

Inca Trail: Warmiwañusqa “Dead Woman's Pass” (4200 m – highest point, daytime), Pacaymayo (3500–3600 m – usually highest night, similar to Cusco)

Machu Picchu (2400 m)

Venezuela

The world's longest and highest cable car takes you from Merida up to Pico Espejo (4765 m), from which the country's highest point, Pico Bolívar (4981 m) can be accessed by just walking.

New Zealand

Mount Cook (3724 m)

You will naturally breathe faster at higher altitudes to compensate for the lower air pressure. It’s possible you won’t notice this: a similar effect happens during air travel. This is called “hypoxic ventilatory response” (HVR); it is frequently misnamed “hyperventilation”.

Increased urine output is a response to hypoxia: increased breathing reduces CO2 in the blood, resulting in more output of bicarbonate, which increases urination. This will make you urinate a lot at altitude. If you aren’t urinating much more than you usually would, then you might actually be dehydrated, or not acclimatizing.

Because of the disruption to oxygen and carbon dioxide levels in your blood due to the body chemistry changes and hyperventilation that occurs at altitude, your body’s “when to breathe” chemical signals become confused. While you’re awake you will remember to breathe, but when you sleep it is common to have interrupted breathing: holding your breath for up to fifteen seconds and then breathing very rapidly when you start breathing again.

This can be very alarming when you wake up knowing that you weren’t breathing or were short of breath; or when you notice someone else has stopped breathing. But it is a normal response to altitude, and happens to almost everyone. Acclimatisation only improves it a little.

You need to increase your fluid intake at high altitudes. The loss of appetite, a precursor to nausea, can lead you in to a dehydration headache. Unfortunately, it is easy to mistake dehydration headaches for acute mountain sickness (AMS) headaches (below) and vice versa. If a headache does not improve after drinking a litre of fluids it should be considered as an AMS effect.

Acute mountain sickness (AMS) is the most common unhealthy response to altitude: it's a collection of signs that your body is becoming ill and has not adapted successfully to a higher altitude.

For your own safety, assume any illness at altitude is AMS – denial of AMS is very frequent and dangerous. The most common reasons that people fail to descend as soon as they should are bad assumptions. They assume that having AMS is a sign of weakness; that their level of fitness means they can’t have AMS; or mistake their symptoms for the flu or another illness. Too-aggressive ascent schedules are another cause: if not enough time is budgeted, acknowledging AMS and slowing down may prevent one from successfully summiting a peak, though worsening AMS may well force this anyway.

Assume AMS first: it happens to healthy strong people, and if it turns out you are indeed sick with something else, descending to a lower altitude will make it easier for your body to heal anyway. No matter what, safety always comes first.

In particular, if you’ve recently ascended, and you have a headache and any other symptom, you have AMS. The other signs of AMS vary for different people, but include:

fatigue

dizziness

loss of appetite

nausea or vomiting

confusion

difficulty walking (called gait ataxia)

rattling breath

feeling generally extremely ill

The last three signs in particular are signs that you are becoming quite ill, but you should not wait for the onset of these symptoms before acknowledging you have AMS: they’re fairly reliable indicators of the onset of more serious problems, namely high altitude cerebral edema (HACE) or high altitude pulmonary edema (HAPE).

You and your party should keep an eye on each other for signs of AMS, and if you have AMS, for signs of it worsening. Very sick people can become confused and not realise how ill they are. Loss of appetite is a particularly good sign: anyone who has been walking or climbing at altitude for a day should be hungry for a good meal in the evening.

If you have symptoms of AMS, do not ascend further. Consider descending, or wait a few days to acclimatize and for symptoms to resolve before ascending further.

If you have signs of HACE or HAPE, descend immediately. Your life may depend on it.

High altitude cerebral edema (HACE) is the end-stage of AMS (conversely AMS can be thought of as the mild form of HACE). When you have HACE, your brain swells and stops working properly.

HACE symptoms include a number of signs of mental functions failing: confusion, fatigue and weird behaviour. But the most reliable one is gait ataxia, and you can test it by walking heel to toe along a straight line on the ground. Healthy people can pass this test easily, anyone who has difficulty balancing while they do it is showing signs of HACE.

HACE is extremely serious, and you may only have a few hours to help someone with HACE. The main treatment is descent, but a person experiencing these symptoms will need significant help. Dexamethasone is one drug that can be used to relieve symptoms, but it is just a temporary bridge to give more time for descent.

A 2008 medical study Why Climbers Die On Mount Everest shows HACE as the leading cause of death.

High altitude pulmonary edema (HAPE) is another severe altitude illness. It sometimes occurs in conjunction with AMS or HACE, but sometimes on its own — it's thought to have different causes. When you have HAPE, your lungs fill with fluid. Signs include extreme fatigue; breathlessness (when not due to interrupted breathing — give yourself 30 seconds to recover upon waking); a cough, especially if it is wet and has blood in it; rattling or gurgling breath; chest congestion; very fast heart rate; very fast breathing; and blue extremities. A fever is sometimes present. It most commonly sets in at night.

HAPE is another extremely serious illness, and like HACE should be treated as a critical emergency. Nifedipine is the drug of choice for the treatment of HAPE, but it can only provide temporary relief and rapid descent is very important.

Above 3000 m (10,000 feet), some people experience a periodic breathing during sleep known as Cheyne-Stokes respirations. The pattern begins with a few shallow breaths and increases to deep sighing respirations then falls off rapidly. Respirations may cease entirely for a few seconds and then the shallow breaths begin again. During the period when breathing stops the person often becomes restless and may wake with a sudden feeling of suffocation. This can disturb sleeping patterns, exhausting the climber.

Acetazolamide is helpful in relieving the periodic breathing. This type of breathing is not considered abnormal at high altitudes. However, if it occurs first during an illness (other than altitude illnesses) or after an injury (particularly a head injury) it may be a sign of a serious disorder.

Decompression sickness (DCS, also known as the bends or caisson disease) is a severe illness in which bubbles of nitrogen form in your blood, blocking blood supply to parts of your body. Symptoms include persistent tingling or joint pain, fatigue, itching, rashes, confusion and collapse. Decompression sickness is brought on by extremely sudden changes in air pressure (effectively an increase in altitude), such as loss of cabin pressure in a plane you are flying in. Even a fast ascent to most altitudes (such as by plane) would not normally cause decompression sickness. The exception is for anyone who has recently been scuba diving, who should avoid ascents above the altitude that their dive took place at for between 12 and 24 hours depending on dive activity. See the Scuba diving article for more information.

Acclimatization is the process of getting your body to adapt to the lower oxygen levels by ascending slowly into higher altitudes, spending some time at each one to adapt. It is essential to budget sufficient time, and have a realistic ascent profile: ascend gradually, and leave extra days in case it is necessary to spend extra time acclimatizing. Over-aggressive schedules, such as 6-day ascent/descent of Kilimanjaro, pose very high risk of AMS, and significant risk that you will not successfully complete the expedition due to not having enough time to acclimatize, instead being forced to turn back.

The most important factor is to increase your sleeping elevation (the altitude where you’re spending the night) slowly. If you’re on a hiking or climbing holiday, a typical strategy is to spend a day (or initially part of a day) at a higher altitude and return to a lower altitude to sleep: “climb high, sleep low”. This is particularly used on summit day for a high summit (such as Kilimanjaro), or over a high pass (such as the Inca trail). This also works for people doing winter sports at high altitudes: ski at the top of the resort and sleep at the bottom.

Here are the recommended maximum increases in your sleeping elevation which will stop most people from proceeding to AMS:

Go no higher than 2400 m (8000 feet) the first night.

Increase your sleeping elevation by 300 m (1000 feet) per night after 3000 m (10,000 feet).

Every 1000 m (3000 feet), you should spend a second night at the same altitude. This will be every fourth night if you have been ascending at the maximum pace recommended above.

These guidelines are conservative; the CDC gives somewhat more aggressive guidelines, such as 2750 m (9000 feet) the first day and increase of 500 m per night, particularly for lower elevations (below 3500 m), though it increases the risk. You can, of course, ascend more gradually than these rates. Many people ascending from sea level choose to spend several nights at 2500 m (8000 feet) to 3000 m (10,000 feet) before beginning acclimatization to higher altitude.

During acclimatisation, drink a lot of non-alcoholic drinks, due to increased urination.

The drug Acetazolamide (ACZ) jump-starts and speeds acclimatisation, via the same biological pathway, and is effective in preventing AMS and reducing its severity. However, it is no substitute for a reasonable ascent schedule.

Be particularly wary with oxygen equipment: some tourists have died at altitude when their equipment failed and they were utterly unacclimatized.

Rapid ascents are the opposite of acclimatization; you make a rapid ascent when you're gaining altitude faster than recommended. This may mean climbing and camping higher than recommended, but you can also make an even more rapid ascent by driving to a high altitude location, and flying from low altitude to high altitude is an even more rapid ascent. For example, flying from sea level to Lhasa, Tibet, which is 3700 m (12,000 feet) high, is distinctly unwise. Consider spending a week or so at an intermediate altitude; see Overland to Tibet for some possibilities. If you are going to travel around Tibet — where some inhabited areas are over 5000 m (16,000 feet) and some mountains over 8000 m (26,000 feet), do not set out until you are thoroughly acclimatised in Lhasa. The same is true if you travel to the Andes; destinations such as Cusco, La Paz or the Inca Trail are located well over 3000 m above sea level.

Where possible, avoid ascents more rapid than recommended above, particularly any sudden ascent to 3000 m (10,000 feet) or higher. Even if you are taking Acetazolamide (below) a rapid ascent makes it more likely you'll get AMS and makes AMS progress to serious illness faster, so you will have less time to respond and descend.

Consider road or rail travel rather than flying directly to somewhere with a very high altitude — but remember that the surface option often involves a lot higher altitudes: the Manali-Leh road for example will take you from below 2000 m (7000 feet) to 5000 m (16,000 feet) in less than a day. Or fly in stages, stopping somewhere at moderate altitude in between. If you must fly to any destination about 3000 m (10,000 feet) at least spend a few days at some intermediate destination en route. If flying to a more moderate altitude above 2500 m (8000 feet), you will still want to spend several nights at that altitude before setting off into higher country.

Remember to drink adequately – around one litre extra of fluids per day. Pushing large volumes of water does not protect against AMS, and can give the same symptoms (headaches, nausea, vomiting and more) as severe AMS from electrolyte imbalance.

Some advocate behavior modifications to prevent AMS, notably rest stepping and pressure breathing. The effectiveness in preventing AMS is unclear, but these are widely practiced.

Rest stepping consists of taking one quick step uphill, then locking the downhill knee and putting one’s weight on the lower leg, resting the muscles before the next step. Breathing is also regular: inhale during the step and exhale during the rest. Progress should be slow but steady, adjusting the rest period, rather than taking breaks. Beyond simply slowing the pace and increasing breathing, this is particularly useful during steep ascents, as it reduces endurance demands on the quadriceps.

Pressure breathing consists of forcefully exhaling through pursed lips, and is typically done at a regular pace (every few steps, or indeed every step).

You can use a pulse oximeter to measure your blood oxygen saturation and pulse rate, which can help you detect problems before you get symptoms. These are inexpensive and easily available, with good accuracy. However, interpreting the numbers is complicated: normal readings vary between individuals and change with altitude. As a rule of thumb, within a group, individuals with lower SpO2 (either resting or after exercise) at a given altitude are more likely to develop AMS at higher altitudes, though precise cutoff values are difficult to give. Medical staff at altitude typically carry these, but it is prudent to purchase one (or two, as a backup) yourself.

Refrain from alcohol (due to dehydration) and smoking when you arrive by plane in a high altitude area from lower altitudes. Avoid heavy meals immediately before and after ascending to a higher altitude.

Acetazolamide (ACZ, AZM, sold as Diamox) stimulates your breathing. The drug was originally designed as a treatment for glaucoma, but a side effect of increased breathing rates and depth have proven useful to climbers. It jump-starts and speeds up acclimatization rates, improves periodic breathing, and helps people recover from AMS more quickly. ACZ is primarily taken preventatively (as a prophylaxis: starting a day or two before ascent, and continuing at altitude and during further ascent), and also has some use for treatment.

Acetazolamide is not an absolute preventative measure, particularly in the case of forced ascents. A prescription is necessary, and a doctor should be consulted about proper dosages.

ACZ should be begun prior to leaving town: severe allergic reactions are rare but possible, even with no prior history, and it is safer to be near proper medical facilities.

There are some side effects. Firstly, the drug acts as a diuretic, causing increased urination, and can cause easy dehydration, so drinking plenty of water is important. Secondly, it can cause tingling (pins and needles) of the fingers and toes.

This drug can be useful for people who have had AMS in the past; people on a forced ascent, particularly to a very high altitude (for example, flying into Tibet or La Paz); and anyone who has AMS, particularly if they are choosing not to descend.

Current CDC guidelines are 125 mg, taken twice a day (every 12 hours), starting the day before ascent, and continuing the first 2 days at altitude, or longer if ascent continues. A 250 mg dose is more effective, but side effects are more likely and more severe: it’s recommended if you are higher risk. If you have enough 125 mg pills, you can double the dose to 250 mg if necessary, so if in doubt, it’s prudent to get more than the minimum.

Ibuprofen 600 mg every 8 hours is reasonably effective for prevention of AMS; not as effective as ACZ, but it is cheap, widely available over-the-counter, and is well-tolerated (few/mild side effects). Gingko biloba has some effectiveness for prevention in some trials, for 100–120 mg every 12 hours, taken before ascent.

Caffeine, through either caffeinated beverages, and coca leaves (primarily and legally available in the Andes) widen the blood vessels and thereby help oxygen transport in the body. Though, if you are not used to caffeine, be aware of adverse effects like faster heart-beat. Chewed coca leaves and coca tea have a milder onset and are thus easier on the body but might get you into trouble when facing a drug-check back at home. In the Andes, cocaine is also widely available (though technically illegal), but most people from the west are not used to high-grade cocaine even when they consider themselves "cocaine experts" - it is therefore very unwise to use cocaine to prevent AMS!

Other than supplemental oxygen, one can relieve symptoms of AMS via usual means: treat headaches with headache medication (non-opiate analgesics, like aspirin, acetaminophen (Tylenol), NSAIDs, etc.) and treat nausea and vomiting with anti-nausea drugs (antiemetics, like ondansetron (Zofran)).

ACZ is moderately effective for treating symptoms, but it's more for prevention. Dexamethasone is most effective for rapidly treating moderate to severe symptoms.

Coca leaves, available primarily in Andean regions of Peru and Bolivia (in coca tea, chewing, or in candies), are a mild stimulant and alleviate symptoms to some degree, particularly headaches (like the caffeine in coffee or tea) though they do not speed acclimatisation. Some people find that vegetarian or starchy food helps them somewhat.

Antacids may help with nausea, but do not help with acclimatization. There is the occasional misconception that antacids have some impact on acclimatization, presumably due to confusion between blood acidity (which is related to acclimatization) and stomach acidity (which is not).

If symptoms get worse while staying at the same altitude, you are in danger: descend immediately.

Supplemental oxygen (2 L/minute) will relieve AMS headaches quickly, and resolve AMS over hours; it is also lifesaving in cases of HAPE, and important for HACE. Oxygen typically isn't available in the field, but is available at hospitals, and at some airports, such as Cusco, for arriving passengers. An alternative field treatment is a hyperbaric chamber (high atmospheric pressure tent), which increases the amount of oxygen available in the air.

Other drugs, which are significantly more potent, include dexamethasone, nifedipine, salmeterol (Serevent), sildenafil, temazepam (Temaze), and tadalafil. Dexamethasone prevents and treats AMS and HACE, but primarily used for treatment (with ACZ preferred for prevention), as adjunct to descent, but is also used for summit day on high peaks such as Kilimanjaro and Aconcagua, to prevent abrupt altitude sickness. Nifedipine prevents and ameliorates HAPE, and is generally reserved for people who are susceptible to the condition. Salmeterol (in conjunction with oral therapy), sildenafil, and tadalafil are all used for HAPE prevention.

Some of these drugs are found in capsules sold in China e.g. Gao Yuan Kang (高原康), which contains dexamethasone. Some herbal preparations are also purported to prevent/treat high altitude illness, such as gingko biloba and a combination capsule called Gao Yuan Ning (高原宁), sold in China. The effectiveness of these preparations remains scientifically unproven, although Gao Yuan Ning (高原宁) is used by Chinese military personnel in cases of rapid ascent.

It is extremely important to note that all these drugs can have significant side effects, especially dexamethasone, a potent steroid medication. Tourists are advised to consult their doctor prior to obtaining these medications. Foreign tourists should procure any necessary medications in their home countries and note the ingredients contained in the medications.